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Dr. James J. Hickman

James J. Hickman, Ph.D.
Professor, NanoScience Technology Center (NSTC, Chemistry, Biomedical Sciences)
Phone: 407-823-1925
Fax: 407-882-1156
E-mail: jhickman@ucf.edu
Website: Hickman Hybrid Systems Lab

Education

  • Ph.D. — M.I.T.
  • M.S. — Pennsylvania State University
  • B.A. — Pennsylvania State University

Affiliations

  • Professor, Chemistry, Burnett College of Biomolecular Sciences, and Electrical Engineering

Research

Research Areas: Establish self-assembled monolayers as a tool for creating compatible biological/non-biological interfaces; integration of biological and neuronal-based systems with MEMS devices, primarily microelectronic devices. Utilization of human-on-a-chip systems for preclinical drug discovery, toxicology investigations and artificial intelligence research.

Research interest of the Hybrid Systems Lab: Dr. Hickman published the first serum-free, defined culture system for neuronal systems and extended this from rat to mouse, both embryonic and adult, as well as to human. These defined in vitro systems have now been extended to cardiac, muscle, endothelial, hepatocyte, cancer, kidney and epithelial cells as well as multiple combinations of different cell types, which has culminated by numerous publications of multi-organ systems to evaluate efficacy and toxicity of compounds for application in drug discovery, general toxicology and cosmetics.

Hickman Hybrid Systems Lab
Engineering the interface between biological and non-biological systems to construct next-generation systems for toxicology, drug discovery, and basic biology research.

Current Funding

  • NIH/NINDS: An In Vitro Model of Stem Cell Innervation of Myotubes, Renewal 09/01/2016 to 05/31/2021
  • Florida High Tech Corridor: Surface chemical modification of body-on-a-chip systems to control cell placement on BioMEMS devices and minimize drug absorption in housing. 07/0182016 to 01/31/2020
  • NIH: Advanced human on a chip systems for drug discovery 09/01/2016 to 08/31/2020
  • NIH: Functional integrated human-on-a-chip systems for Alzheimer’s research 09/15/2017 to 10/31/2020
  • NIH: Integration of a kidney track module with a 4-organ human-on-a-chip system 09/15/2017 to 08/31/2019
  • NIH: Human on a chip systems to investigate disease comorbidities common in the aged population 04/01/2018 to 03/31/2023
  • NIH: Development of a Cardiac Ischemia model in an Organ-on-a-Chip Platform 09/01/2018 to 07/31/2019
  • NIH: Development of an integrated 4-organ animal model 09/17/2018 to 08/31/2019

» View previously funded projects

Patents & Publications

Number of publications: 134
Number of patents: 22 (an additional 22 applications in process)
Book chapters: 20


Title of recent papers that have high impact (e.g. high impact factor journals, high citations, etc.),

X. Guo, et al, “Tissue Engineering the Mechanosensory Circuit of the Stretch Reflex Arc with Human Stem Cells: Sensory Neuron Innervation of Intrafusal Muscle Fibers,” Biomaterials 122:179-187 (2017).

A. Colon, et al., “Functional Analysis of Human Intrafusal Fiber Innervation by Human γ-Motoneurons,” Nature Scientific Reports 7:17202; doi:10.1038/s41598-017-17382-2 (2017).

N. Santhanam, et al., “Stem Cell Derived Phenotypic Human Neuromuscular Junction Model for Dose Response Evaluation of Therapeutics,” Biomaterials 166:64-78, 2018.

B. Berry, et al., “Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer’s Disease Phenotype in iPSC Derived Human Neurons,” ACS Chemical Neuroscience 9:1693-1701 (2018).

C. Oleaga, et al., “Investigation of the Effect of Hepatic Metabolism on Off-Target Cardiotoxicity in a Multi-Organ Human-On-A-Chip System,” Biomaterials 182:176-190 (2018).

Journal cover for our paper in Advanced Functional Materials

C. Oleaga, et al., “Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System,” Advanced Functional Materials, online first (2018) DOI: 10.1002/adfm.201805792.

Selected Publications

2018

Carlota Oleaga, Andrea Lavado, Anne Riu, Sandra Rothemund, Carlos A. Carmona-Moran, Keisha Persaud, Andrew Yurko, Jennifer Lear, Narasimhan Sriram Narasimhan, Christopher J. Long, Frank Sommerhage, Lee Richard Bridges, Yunqing Cai, Candace Martin, Mark T. Schnepper, Arindom Goswami, Reine Note, Jessica Langer, Silvia Teissier, José Cotovio, and James J. Hickman* Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System. Advanced Functional Materials

L. Ewart, E.-M. Dehne, K. Fabre, Susan Gibbs, J. Hickman, E. Hornberg, M. Ingelman-Sundberg, K.-J. Jang, D.R. Jones, V.M. Lauschke, U. Marx, Jerome T. Mettetal, A. Pointon, D. Williams, W.-H. Zimmermann, and P. Newham, “Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery,” Annual Review of Pharmacology and Toxicology 58:65-82 (2018).

J. van der Valk, K. Bieback, C. Buta, B. Cochrane, W.G. Dirks, J. Fu, J.J. Hickman, C. Hohensee, R. Kolar, M. Liebsch, F. Pistollato, M. Schulz, D. Thieme, T. Weber, J. Wiest, S. Winkler and G. Gstraunthaler, “Fetal Bovine Serum (FBS) Past – Present – Future,” ALTEX 35:99-118 (2018)

N. Santhanam, L. Kumanchik, X. Guo, F. Sommerhage, Y. Cai, M. Jackson, C. Martin, G. Saad, C.W. McAleer, Y. Wang, A. Lavado, C.J. Long, J.J. Hickman, “Stem Cell Derived Phenotypic Human Neuromuscular Junction Model for Dose Response Evaluation of Therapeutics,” Biomaterials 166:64-78, 2018.

B. Berry, A.S.T. Smith, C. J. Long, C. Martin and J.J. Hickman, “Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer’s Disease Phenotype in iPSC Derived Human Neurons,” ACS Chem Neurosci in press, 2018.

2017

X. Guo, A. Colon, N. Akanda, S. Spradling, M. Stancescu, C. Martin, J.J. Hickman, “Tissue Engineering the Mechanosensory Circuit of the Stretch Reflex Arc with Human Stem Cells: Sensory Neuron Innervation of Intrafusal Muscle Fibers,” Biomaterials 122:179-187 (2017).

Y. Wang, C. Oleaga, C. Long, M.B. Esch, C. McAleer, P.G. Miller; J.J. Hickman and M.L. Shuler, “Self-contained, Low-cost Body-on-a-Chip Systems for Drug Development," Experimental Biology and Medicine Online 0:1-13 DOI:10.1177/1535370217694101 (2017).

J. van der Valk, K. Bieback, C. Buta, B. Cochrane, W.G. Dirks, J. Fu, J.J. Hickman, C. Hohensee, R. Kolar, M. Liebsch, F. Pistollato, M. Schulz, D. Thieme, T. Weber, J. Wiest, S. Winkler and G. Gstraunthaler, “Fetal Bovine Serum (FBS): Past – Present – Future,” ALTEX: Alternatives to Animal Experimentation Online August 9, 2017; doi:10.14573/ altex.1705101 (2017).

Y.I. Wang, C. Carmona, J.J. Hickman and M.L. Shuler, “Multi-Organ Microphysiological Systems for Drug Development: Strategies, Advances and Challenges,” Advanced Healthcare Materials 242: 1701–1713; doi.org/10.1002/adhm.201701000 (2017).

A. Colon, X. Guo, N. Akanda, Y. Cai and J.J. Hickman, “Functional Analysis of Human Intrafusal Fiber Innervation by Human γ-Motoneurons,” Nature Scientific Reports 7:17202; doi:10.1038/s41598-017-17382-2 (2017).

D. Edwards, F. Sommerhage, B. Berry, H. Nummer, B. Clymer, M. Stancescu, J.J. Hickman, “Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems,” ACS Biomaterials Science & Engineering 3:3525-3533 (2017).

A. Lavado, X. Guo, N. Akanda, C. Martin, Y. Cai, D. Elbrecht, M. Tran, J.-P. Bryant, A. Colon, C.J. Long, S. Lambert, D. Morgan and J.J Hickman, “Evaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential,” International Journal of Pharmacy and Pharmaceuticals 11:348-374 (2017).

2016

Mahler G.J., Esch M.B., Stokol T., J.J. Hickman, M.L. Shuler. 2016. Body-on-a-chip systems for animal-free toxicity testing. Altern Lab Anim.

Sakolish, C.M., M.B. Esch, J.J. Hickman, M.L. Shuler, and G.J. Mahler. 2016. Modeling barrier tissues in vitro: methods, achievements, and challenges. E Bio Medicine. [link]

Sakolish, C.M., M.B. Esch, J.J. Hickman, M.L. Shuler, and G.J. Mahler. 2016. Modeling barrier tissues in vitro: methods, achievements, and challenges. E Bio Medicine. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816829/

C. Oleaga, C. Bernabini, A.S.T. Smith, B. Srinivasan, M. Jackson, W. McLamb, V. Platt, R. Bridges, Y. Cai, N. Santhanam, B. Berry, S. Najjar, N. Akanda, X. Guo, C. Martin, G. Ekman, M.B. Esch, J. Langer, G. Ouedraogo, J. Cotovio, L. Breton, M.L. Shuler and J.J. Hickman “Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs” Scientific Reports (6):20030 (2016)

2015

B.J. Berry, N. Akanda, A.S.T. Smith, C.J. Long, M.T. Schnepper, X. Guo and J.J. Hickman, “Functional Characterization of Human Induced Pluripotent Stem Cell Neurons in Different Defined Culture Systems,” Biotechnology Progress 31(6):1613-1622 (2015).

Abaci, H.E., and M.L. Shuler. 2015. Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr Biol, 1:383-391

Srinivasan, B., Kolli, A.R., Esch, M.B., Abaci, H.E., Shuler, M.L., and J.J. Hickman. 2015. TEER measurement techniques for in vitro barrier model systems. J Lab Automation. 20:107-126

B. Srinivasan, A.R. Kolli, M.B. Esch, H.E. Abaci, M.L. Shuler and J.J. Hickman, “TEER Measurement Techniques for Organs-On-Chips Systems,” JALA 20(2):107-126 (2015).

C. McAleer, J.W. Rumsey, M. Stancescu and J.J. Hickman, “Functional Myotube Formation from Adult Rat Satellite Cells in a Defined Serum-Free System,” Biotechnology Progress 31(4):997-1003 (2015).

M. Stancescu, P. Molnar, C. McAleer, W. McLamb, C. Long, C. Oleaga, J.-M. Prot and J.J. Hickman, “In Vitro Model of Whole Heart Function,” Biomaterials 60:20-30 (2015).

B.J. Berry, N. Akanda, A.S.T. Smith, C.J. Long, M.T. Schnepper, X. Guo and J.J. Hickman, “Functional Characterization of Human Induced Pluripotent Stem Cell Neurons in Different Defined Culture Systems,” Biotechnology Progress in press (2015).

2014

C.W. McAleer, A.S.T. Smith, S. Najjar, K. Pirozzi, C.J. Long and J.J. Hickman, “Mechanistic Investigation of Adult Myotube Response to Exercise and Drug Treatment in Vitro Using a Multiplexed Functional Assay System,” J Appl Physiol 117(11):1398-1405 (2014).

Esch, M.B., Smith, A., Prot, J.M., Oleaga, C., Hickman, J., and Shuler, M.L. 2014. How Multi-Organ Microdevices Can Help Foster Drug Development. Advanced Drug Delivery Reviews, 69-70 (2014) 158-169.

Shuler, M.L. and J.J. Hickman. 2014. Toward in virtro models of brain structure and function. PNAS. 111(38): 13682-13683.

Sung, J.H., Srinivasan, B., Esch, M.B., McLamb, W.T., Bernabini, C., Shuler, M.L., and J.J. Hickman. 2014. Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure. Experimental Biology and Medicine. 239:1225-1239.

X. Guo, K. Greene, N. Akanda, A.S.T. Smith, M. Stancescu, S. Lambert, H. Vandenburgh, and J.J. Hickman, “In vitro Differentiation of Functional Human Skeletal Myotubes in a Defined System,” Biomaterials Science 2:131-138 (2014).

A.S.T. Smith, C.J. Long, B.J. Berry, C. McAleer, M. Stancescu, P. Molnar, P.G. Miller, M.B. Esch, J.-M. Prot, J.J. Hickman and M.L. Shuler, “Microphysiological systems and low cost microfluidic platform with analytics,” Stem Cell Research and Therapy in press (2014).

M. B. Esch, A.S.T. Smith,J.-M. Prot, C. Oleaga, J.J. Hickman and M.L. Shuler “How Multi-Organ Microdevices Can Help Foster Drug Development” ADDR in press (2014).

J.H. Sung, M.B. Esch, W.T. McLamb, C. Bernabini, B. Srinivasan, M.L. Shuler and J.J. Hickman, “Using PBPK guided “Body-on-a-Chip” Systems to Predict Mammalian Response to Drug and Chemical Exposure,” accepted to Experimental Biology and Medicine (2014).

A.S.T. Smith, C.J. Long, C. McAleer, N. Bobbitt, B. Srinivasan and J.J. Hickman, “Utilization of microscale silicon cantilevers to assess cellular contractile function in vitro,” accepted to JoVE (2014).

M. Ramalingam, P, Molnar and J.J. Hickman, “Surface Patterning of Biomaterials to Control Cell Behavior,” Encyclopedia of Nanoscience and Nanotechnology(ENN) American Scientific Publishers, Valencia, California, in press.

2013

Smith, A.S., Long, C.J., Berry, B.J., Mcaleer, C., Molnar, P., Miller, P.G., Esch, M.B., Prot, J.M., Hickman, J.J. and Shuler, M.L. 2013. Microphysiological systems and low-cost microfluidic platform with analytics. Stem Cell Res Ther. DOI: 10.1186/scrt370. PMID: 24565109. Epub 2013 Dec 20

Angus, et al. 2013. A physical sciences network characterization of non-tumorigenic and metastatic cells, Sci. Rep. 3:14493 DOI:10.1038/srep01449

S.A. Khan, V. Thakore, A. Behal, L. Bölöni and J.J. Hickman, “Comparative analysis of system identification techniques for nonlinear modeling of the neuron-microelectrode junction,” Journal of Computational and Theoretical Nanoscience, 10(3):573-580 (2013).

A. Natarajan, T. DeMarse, P. Molnar, J.J. Hickman, “Engineered In Vitro Feed-Forward Networks,” Journal of Biotechnology and Biomaterials 3(1):153 (2013).

X. Guo, S. Spradling, M. Stancescu, S. Lambert, J.J. Hickman, “Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1,” Biomaterials 34:4418-4427 (2013).

J.H. Sung, M.B. Esch, J.-M. Prot, C.J. Long, A. Smith, J.J. Hickman and M.L. Shuler, “Microfabricated mammalian organ systems and their integration into models of whole animals and humans,” Lab on a Chip 13:1201-1212 (2013).

C. Finch, T. Clarke, and J.J. Hickman, “A Continuum Hard-Sphere Model of Protein Adsorption,” Journal of Computational Physics, 244:212-222 (2013).

J.W. Rumsey, C. McAleer, M. Das, A. Bhalkikar, K. Wilson, M. Stancescu, S. Lambert, J.J. Hickman, “Myelination and node of Ranvier formation on sensory neurons in a defined in vitro system,” In Vitro Cell Dev Biol Anim, 49:608-618 (2013).

K.L. Pirozzi C.J. Long, C.W. McAleer, A.S.T. Smith and J.J. Hickman, “Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an Atomic Force Microscopy-based bio- Microelectromechanical systems device,” Applied Physics Letters, 103:083108 (2013).

D. Edwards, M. Stancescu, P. Molnar and J.J. Hickman, “Two cell networks of oriented adult hippocampal neurons on self-assembled monolayers for use in the study of neuronal communication in a defined system,” ACS Chemical Neuroscience 4:1174-1182 (2013) DOI: 10.1021/cn300206k

A.S.T. Smith, C.J. Long, Kristen Pirozzi and J.J. Hickman, “Development of a functional system for high-content screening of neuromuscular junctions,” Technology, 1(1):37-48 (2013).

2012

K.A. Wilson, C. A. Finch, P. Anderson, F. Vollmer, and J.J. Hickman, “Whispering Gallery Mode Biosensor Quantification of Fibronectin Adsorption Kinetics onto Alkylsilane Monolayers and Interpretation of Resultant Cellular Response” Biomaterials 33:225-236 (2012).

H. Davis, X. Guo, S. Lambert, M. Stancescu and J.J. Hickman, “Small Molecule Induction of Human Umbilical Stem Cells into MBP-Positive Oligodendrocytes in a Defined Three-Dimensional Environment,” ACS Chemical Neuroscience, 3:31-39 (2012).

X. Guo, J.E. Ayala1, M. Gonzalez, M. Stancescu, S. Lambert, J.J. Hickman, “Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons” Biomaterials, 33(23):5723-5731 (2012).

C. Long, C. Finch, M. Esch, W. Anderson, M. Shuler and J.J. Hickman, “Design Optimization of Liquid-Phase Flow Patterns for Microfabricated Lung On A Chip” Annals of Biomedical Engineering, 40(6):1255-1267 (2012).

J. Chen, L. Zhi, P. Molnar, J.J. Hickman, A. Behal, “A Weighted Least Squares Approach for Identification of a Reduced-Order Adaptive Neuronal Model” accepted to IEEE Transactions on Neural Networks and Learning Systems (2012).

H. Davis, M. Gonzalez, N. Bhargava, M. Stancescu, J.J. Hickman, and S. Lambert, “Rat Cortical Oligodendrocyte–Embryonic Motoneuron Co-culture: An in vitro Axon-Oligodendrocyte Interaction Model,” accepted to the Journal of Biomaterials & Tissue Engineering, (2012).

S.A. Khan, V. Thakore, A. Behal, L. Bölöni and J.J. Hickman, “Comparative Analysis of System Identification Techniques for Nonlinear Modeling of the Neuron-Microelectrode Junction,” accepted to the Journal of Computational and Theoretical Nanoscience, (2012).

C. Finch, T. Clarke, and J.J. Hickman, “A Continuum Hard-Sphere Model of Protein Adsorption,” accepted to the Journal of Computational Physics, (2012).

V. Thakore, P. Molnar and J.J. Hickman, “An Optimization Based Study of Equivalent Circuit Models for Representing Recordings at the Neuron-Electrode Interface,” accepted to the IEEE Transactions on Biomedical Engineering (2012).

C.N. Baker, D.G. Taylor, K. Osuala, A. Natarajan, P. Molnar, J.J. Hickman, S. Alam, B. Moscato, D. Weinshenker, and S.N. Ebert, “Adrenergic Deficiency Leads to Impaired Electrical Conduction and Increased Arrhythmic Potential in the Embryonic Mouse Heart,” accepted to Biochemical and Biophysical Research Communications, (2012).

C. Wang, J. Reed, L. Ma, Y. Qiao, Y. Luo, S. Zou, J.J. Hickman and M. Su, “Biomimic Light Trapping Silicon Nanowire Arrays for Laser Desorption/Ionization of peptides” accepted to Journal of Physical Chemistry (2012).

2011

A. Natarajan, M. Stancescu, V. Dhir, C. Armstrong, F. Sommerhage, J.J. Hickman and P. Molnar, "Patterned Cardiomyocytes on Microelectrode Arrays as a Functional, High Information Content Drug Screening Platform" Biomaterials 32(18):4267-4274 (2011)

K. Wilson, M. Stancescu, M. Das, J. Rumsey and J.J. Hickman, “Direct patterning of coplanar polyethylene glycol alkylsilane monolayers by deep-ultraviolet photolithography as a general method for high fidelity, long-term cell patterning and culture” JVST B 29(2):DOI:10.1116/1.3549127 10 pgs (2011).

X. Guo, M. Gonzalez, M. Stancescu, H. Vandenburgh and J.J. Hickman, “Neuromuscular Junction Formation between Human Stem cell-derived Motoneurons and Human Skeletal Muscle in a Defined System,” Biomaterials 32:9602-9611 (2011).

M. Ramalingam, P, Molnar and J.J. Hickman, “Surface Patterning of Biomaterials to Control Cell Behavior,” Encyclopedia of Nanoscience and Nanotechnology (ENN) American Scientific Publishers, Valencia, California, in press.

X. Guo and J.J. Hickman. “Treatment of ALS utilizing a stem cell strategy” in Motor Neuron Diseases: Causes, Classification and Treatments, Nova Science Publishers, Hauppauge, New York. In press.

2010

M.S. Ravenscroft-Chang, J. Stohlman, P. Molnar, A. Natarajan, H.E. Canavan, M. Teliska, M. Stancescu, V. Krauthamer and J.J. Hickman, "Altered Calcium Dynamics in Cardiac Cells Grown on Silane-Modified Surfaces" Biomaterials 31:602-607 (2010).

C.M. Smith, T.D. Roy, A. Bhalkikar, B. Li, J.J. Hickman and K.H. Church, "Engineering a Titanium and Polycaprolactone Construct for a Biocompatible Interface Between the Body and Artificial Limb," Tissue Engineering Part A, 16(2):717-724 (2010).

X.F. Guo, K. Johe, P. Molnar, H. Davis, J.J. Hickman, "Characterization of a Human Spinal Cord Stem Cell Line and Its Induction to Motoneurons," Tissue Engineering and Regenerative Medicine 4:181-193 (2010).

K. Varghese, P. Molnar, M. Das, N. Bhargava, S. Lambert, M.S. Kindy and J.J. Hickman, "A New Target for Amyloid Beta Toxicity Validated by Standard and High-throughput Electrophysiology," PLoS One 5(1): e8643.doi:10.1371/journal.pone.0008643 (2010).

M. Das, J.W. Rumsey, N. Bhargava, M. Stancescu and J.J. Hickman, "A Defined Long-Term In Vitro Tissue Engineered Model of Neuromuscular Junctions" Biomaterials 31:4880-4888 (2010).

D. Edwards, M. Das, P. Molnar and J.J. Hickman, "Addition of Glutamate to Serum Free Culture Promotes Recovery of Electrical Activity in Adult Hippocampal Neurons In Vitro" J Neuroscience Methods 190:155-163 (2010).

X. Guo, M. Das, J. Rumsey, M. Gonzalez, M. Stancescu and J.J. Hickman, "Neuromuscular Junction Formation between Human Stem Cell derived Motoneurons and Rat Skeletal Muscle in a Defined System" Tissue Engineering, Part C, 16(6):1347-1355 (2010).

N. Bhargava, M. Das, D. Edwards, M. Stancescu, J.-F. Kang and J.J. Hickman, "Coexpression of Glutamate Vesicular Transporter (VGLUT1) and Choline Acetyltransferase (ChAT) Proteins in Embryonic Rat Hippocampal Neurons in Culture" In Vitro Cell Dev Animal 46:685-692 (2010).

J.W. Rumsey, M. Das, A. Bhalkikar, M. Stancecsu and J.J. Hickman, "Tissue Engineering the Mechanosensory Circuit of the Stretch Reflex Arc: Sensory Neuron Innervation of Intrafusal Muscle Fibers" Biomaterials 31:8218-8227 (2010).

C. Wang, M. Hossain, L. Ma, Z. Ma, J.J. Hickman, M. Su, "Highly sensitive thermal detection of thrombin using aptamer-functionalized phase change nanoparticles" Biosensors & Bioelectronics 26(2):437-443 (2010).

J.C. Henderson, M. Yacopucci, C.J. Chun, K. Lenghaus and J.J. Hickman, "Investigation of the Behavior of Serum Plasma in a Microfluidics System," JVST B 28(5):1066-1069 (2010).

M. Ramalingam, P, Molnar and J.J. Hickman, "Surface Patterning of Biomaterials to Control Cell Behavior," Encyclopedia of Nanoscience and Nanotechnology (ENN) American Scientific Publishers, Valencia, California, in press.

M. Ramalingam, S.S. Liao, S. Ramakrishna, P. Molnar, Z.M. Huang, M. Kotaki, K. Panduranga Rao and J.J. Hickman, "Skeletal Regeneration Nanobiomaterials," in Biomaterials for Bone Regenerative Medicine, TTP Publishers, Swiss/USA, in press.

H. Davis, X. Guo, S. Lambert, M. Stancescu and J.J. Hickman, "Small Molecule Induction of Human Umbilical Stem Cells into MBP-positive Oligodendrocytes in a Defined Three-Dimensional Environment" (submitted to Nature Biotechnology).

2009

K. Varghese, M. Das, N. Bhargava, P. Molnar, M.S. Kindy and J.J. Hickman, "Regeneration and characterization of adult mouse hippocampal neurons in a defined in vitro system," Journal of Neuroscience Methods 177:51-50 (2009).

M. Ramalingam, P. Molnar, K. P. Rao and J.J. Hickman, "Biomaterial Surface patterning utilizing self assembled monolayers to control neuronal cell behavior", International Journal of Biomedical Engineering and Technology, Review 2(2):104 - 134 (2009).

J.W. Rumsey, M. Das, M. Stancescu, M. Bott, C. Fernandez-Valle and J.J. Hickman, "Node of Ranvier formation on motoneurons in vitro" Biomaterials 30:3567-3572 (2009).

T. Xu, P, Molnar, C. Gregory, M. Das, T. Boland and J.J. Hickman, "Electrophysiological Characterization of Embryonic Hippocampal Neurons Cultured in 3D Collagen Hydrogel," Biomaterials 30:4377-4383 (2009).

M. Das, J. W. Rumsey, N. Bhargava, M. Stancescu and J.J. Hickman, "Skeletal Muscle Tissue Engineering: An Improved Model Promoting Long Term Survival of Myotubes, Structural Development of E-C Coupling Apparatus and Neonatal Myosin Heavy Chain (MHC) Expression," Biomaterials 30:5392-5402 (2009).

M. Das, J.W. Rumsey, N. Bhargava, C. Gregory, L. Riedel, J.F. Kang, J.J. Hickman, "Developing a Novel Serum-Free Cell Culture Model of Skeletal Muscle Differentiation by Systematically Studying the Role of Different Growth Factors in Myotube Formation," In Vitro Cell Dev Biol Animal 45:378-387 (2009).

N. Akanda, M. Stancescu, P. Molnar and J.J. Hickman, "Analysis of Toxin Induced Changes in Action Potential Shape for Drug Development," Journal of Biomolecular Screening 14(10):1228-1235 (2009).

N. Bhargava, M. Das, A. S. Karakoti, S. Patil, J.F. Kang, M. Stancescu, M. S. Kindy, S. Seal and J.J. Hickman, "Regeneration of Adult Mice Motoneurons Utilizing a Defined System and Anti-oxidant Nanoparticles," Journal of Nanoneuroscience 1(2):130-143 (2009).

D.G. Taylor, A. Natarajan, B. Moscato, P. Molnar, J.J. Hickman, S.N. Ebert, "Adrenergic Deficiency Leads to Slowed Ventricular Conduction and Increased Arrhythmias in Embryonic Mouse Hearts" Circulation 120(18):S616 (2009).

2008

M. Ramalingam, P, Molnar and J.J. Hickman, "Nano-Surface Patterning Techniques for Cell Studies," Encyclopedia of Nanoscience and Nanotechnology (ENN) American Scientific Publishers, Valencia, California, (2008)

M. Ramalingam, S. Ramakrishna and J.J. Hickman, "Cell Responsive Nano-fibrous Materials for Tissue Engineering," in Encyclopedia of Nanoscience & Nanotechnology, American Scientific Publishers, Ed. Hari Singh Nalwa, Valencia, California. (2008)

M. Das, N. Bhargava, A. Bhalkikar, J. F. Kang and J.J. Hickman, "Temporal Neurotransmitter Conditioning Restores the Functional Activity of Adult Spinal-Cord Neurons in Long-Term Culture" Experimental Neurology 209:171-180 (2008).

J. W. Rumsey, M. Das, J. F. Kang, R. Wagner, P. Molnar and J.J. Hickman, "Tissue Engineering Intrafusal Fibers: Dose and Time Dependent Differentiation of Nuclear Bag Fibers in a Defined In Vitro System using Neuregulin 1-β-1" Biomaterials 29:994-1104 (2008).

J. Liu, J.W. Rumsey, P. Molnar, M. Das, C. Gregory, L. Riedel and J.J. Hickman, "Electrophysiological and Immunocytochemical Characterization of DRG Neurons on an Organosilane Surface in Serum Free Medium" In Vitro Cellular & Developmental Biology 44:162-168 (2008)

J. Rolland, K-S. Lee, A. Mahmood, L. Fluck, J. Duarte, I. Kaya, A. Santhanam, P. Meemon, S. Murali, O. Ilegbusi, P. Kupelian, A.M. Kachurin, W.L. Warren, P. Molnar, J.J. Hickman and P.K. Kolattukudy, Eds J.D. Westwood, R.S. Haluck, H.M.Hoffman, G.T. Mogel, R. Phillips, R.A. Robb, K.G. Vosburgh, "Collaborative Engineering: 3-D Optical Imaging and Gas Exchange Simulation of In-Vitro Alveolar Constructs", in Studies in Health Technolology Informatics 132:426-432 (2008).

A. Natarajan, C.J. Chun, J.J. Hickman and P. Molnar, "Growth and Electrophysiological Properties of Rat Embryonic Cardiomyocytes on Hydroxyl- and Carboxyl-Modified Surfaces," Journal of Biomaterials Science: Polymer Edition 19(10):1319-1331 (2008).

V. Thakore, A. Behal, P. Molnar, D.C. Leistritz, and J.J. Hickman, "Nanoscale Nonlinear Dynamic Characterization of the Neuron-Electrode Junction" J. Comput. Theor. Nanosci. 5(11):2164-2169 (2008).

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